Shining a Light on How Early Tau-Related Brain Changes Affect Memory Loss
Principal Investigator
Mentors
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Ulman Lindenberger, PhD
Project Goals
This project delves into the brainstem’s role in early tau accumulation and memory loss via advanced magnetic resonance imaging, plasma biomarkers, and long-term data, enhancing our understanding of Alzheimer's progression.
Project Summary
This project spotlights previously understudied brain regions—tiny nuclei in the brainstem—that are the starting point of Alzheimer's-related tau accumulation and investigates how their changes contribute to memory loss. Using innovative brain imaging techniques, blood-based biomarkers, and memory assessments collected over a decade from a large number of participants, this project improves our understanding of the time course of neural changes in later life and their mechanistic role in the earliest stages of Alzheimer's development.
Publications
First published on: July 29, 2024
Last modified on: September 10, 2024