Shining a Light on How Early Tau-Related Brain Changes Affect Memory Loss

Project Summary

This project spotlights previously understudied brain regions—tiny nuclei in the brainstem—that are the starting point of Alzheimer's-related tau accumulation and investigates how their changes contribute to memory loss. Using innovative brain imaging techniques, blood-based biomarkers, and memory assessments collected over a decade from a large number of participants, this project improves our understanding of the time course of neural changes in later life and their mechanistic role in the earliest stages of Alzheimer's development.