The Role of the Immune System in Alzheimer's Disease

Project Summary

Alzheimer’s disease has traditionally been considered a neuronal pathology, but now it is known that a specific type of brain immune cell, called microglia, plays a crucial role in the pathogenesis of the disease. This project aims to understand how immune cells from the blood impact microglia and contribute to the development of Alzheimer’s disease. 

This project will use human samples, enabling researchers to obtain potential translational results for the clinic. The characterization and validation of a peripheral immune mechanism that contributes to Alzheimer’s pathology could offer important biomarkers for disease diagnosis and the design of new therapies.

Yearbook: It is known that a specific type of brain immune cell, called microglia, plays a crucial role in the pathogenesis of Alzheimer’s disease. This project aims to understand how immune cells from the blood impact microglia and contribute to the development of Alzheimer’s. The characterization and validation of a peripheral immune mechanism that contributes to Alzheimer’s pathology could offer important biomarkers for disease diagnosis and the design of new therapies.