Circadian Rhythm Disruption and Alzheimer's Disease
Principal Investigator
Mentors
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Erik Musiek, MD, PhD
Project Goals
The project investigates how the circadian rhythm disruptions, like chronic jetlag or shiftwork, affect Alzheimer's disease progression, focusing on amyloid plaques, tau pathology, and inflammation.
Project Summary
This study investigates how disruptions to circadian rhythms, common in aging and Alzheimer's disease, impact disease progression using a mouse model of chronic jetlag (CJL). Researchers aim to understand how CJL affects Alzheimer’s markers—amyloid plaques and tau protein accumulation. Investigating the connection between circadian disruption, glial function, and Alzheimer’s-related changes may reveal therapeutic strategies, offering novel approaches to disease prevention.
Publications
First published on: October 09, 2024
Last modified on: October 16, 2024