Targeting Neuroinflammation for RGC Protection in Glaucoma
The proposed research studies a novel protein that was recently identified as a key regulator of macrophages, a type of immune cells, that are activated during glaucoma. Using genetic tools and animal models, the study will explore how this protein regulates macrophage activation and inflammation in the retina of glaucoma eyes. Furthermore, the study will develop a novel therapy using small vesicles secreted from bone marrow stem cells to manipulate macrophage behavior and protect retinal neurons in glaucoma. Completion of the project will help understand how glaucoma damages retinal neurons and develop new treatment to reduce retinal damage and preserve vision in glaucoma.