The Role of Thrombospondin-1 in Regulating IOP
This research project aims to determine the role of thrombospondin-1 (TSP1) in regulating intraocular pressure (IOP) and outflow facility. In specific aim 1, we plan to determine whether TSP1 deficiency prevents or reduces steroid-induced ocular hypertension and its underlying mechanisms using a mouse model. In specific aim 2, we plan to determine whether TSP1 reduces outflow facility in ex vivo perfused porcine eyes and what hydrodynamic and morphological changes may be responsible for this reduction. The results from the proposed research will provide a better understanding of the molecular mechanisms involved in IOP regulation and have the potential for developing novel therapeutic strategies by targeting TSP1 to lower IOP in glaucoma.