The Role of MicroRNAs in Regulating Aqueous Humor Outflow
Principal Investigator
Project Goals
The most effective therapy for glaucoma is reducing eye pressure, but it is not understood how the pressure in the eye is regulated. MicroRNAs (miRNAs) are very small genetic sequences that can regulate the expression of many genes. In fact, a single miRNA is so powerful that it can modulate several genes. The aim of this project is to understand the role of a very important miRNA in regulating intraocular pressure (IOP). This may be a very effective new way to treat elevated eye pressure in glaucoma.
Project Summary
Primary open angle glaucoma (POAG) is an irreversible eye blinding disease. Schlemm’s canal (SC) inner wall and juxtacanalicular (JCT) tissue are thought to be the sites of major aqueous outflow resistance, which is responsible for elevated eye pressure characteristic of many cases of POAG. Therefore it is important to understand how SC cells regulate eye pressure. Our early work suggest that miRNAs participate eye pressure regulation, it this project we will use molecular biology and pharmacology techniques to understand the mechanism of such regulations. This work might pave the way to the discovery of a new pathway that controls IOP.
Publications
Hu C, Sun J, Zhang Y, Chen J, Lei Y, Sun X, Deng Y. Local Delivery and Sustained-Release of Nitric Oxide Donor Loaded in Mesoporous Silica Particles for Efficient Treatment of Primary Open-Angle Glaucoma. Adv Healthc Mater. 2018 Dec;7(23):e1801047. doi: 10.1002/adhm.201801047. Epub 2018 Nov 2. PubMed PMID: 30387326 
First published on: July 27, 2018
Last modified on: May 02, 2024