The Role of Brain Waste Clearance System in Glaucoma
Detailed Non-Technical Summary
The overall goal of this project is to better understand glaucoma mechanisms by determining the pathophysiological events and disease progression in the brain’s visual system using novel, multi-parametric magnetic resonance imaging techniques in experimental glaucoma models. Currently, the only clinically proven glaucoma intervention is lowering intraocular pressure in afflicted individuals. However, glaucoma may continue to progress in some patients even after lowering intraocular pressure to normal levels, which indicates that other undetermined key factors may be contributing to the disease. The results of this study will not only provide new insights into the brain involvements that occur during the process of glaucomatous neurodegeneration, but also are likely to suggest new strategies for targeting glaucoma treatment beyond lowering eye pressure.