Pressure-Induced Axon Damage and Its Link to Glaucoma-Related Vision Loss

Project Goals

Researchers aim to quantify the intraocular eye pressure (IOP)-related axonal insult and its correlation with chronic neural tissue loss in order to enable early-stage glaucoma prediction and develop tools to prevent vision loss.

Project Summary

Blindness in glaucoma is caused by damage to axons that carry visual information to the brain. Damage often starts in the back of the eye and is due to high eye pressure which mechanically deforms axons. However, the link between axon deformation and long-term damage is unclear. Using animal models, researchers will investigate axon deformation and its link to damage to understand glaucoma’s causes.

Publications

First published on: August 05, 2024

Last modified on: November 19, 2024