Novel Genetic Mouse Model of Early-Onset Glaucoma

Project Summary

We have characterized a mouse model of glaucoma that recapitulates features of early-onset glaucoma in humans. Mouse studies provide an important extension to human studies that allows detailed mechanistic understanding. Findings from the proposed studies will lead to a better understanding of the molecular mechanisms contributing to elevated intraocular pressure, a major risk factor for glaucoma. Importantly, it has potential to provide us with a robust new genetic mouse model to study glaucomatous neurodegeneration, which is much needed to advance glaucoma research. Uncovering the molecular basis of a disease is key to development of therapeutic intervention(s) to prevent/slow down glaucoma progression.