Neuroprotection and Neuroenhancement in Glaucoma
![Jeffrey Goldberg, MD, PhD](https://www.brightfocus.org/wp-content/uploads/2024/10/NGR_Jeffrey_Goldberg-1.jpg)
About the Research Project
Program
Award Type
Bold Ideas initiatives
Award Amount
$479,072
Active Dates
May 01, 2022 - April 30, 2025
Grant ID
CG2022001
Goals
The goal of this project is to evaluate safety and proof of concept for whether CNTF can enhance vision or protect against vision loss in glaucoma.
Summary
This is a randomized, controlled, single masked trial extension of a phase 2 clinical trial in human patients with glaucoma. The trial will evaluate the retina and optic nerve in patients using a series of advanced structure and function testing modalities (biomarkers), to increase the chance of detecting evidence of neuroenhancement (vision improvement) or neuroprotection (protection against vision loss).
Unique and Innovative
This clinical trial is one of the very few in the world studying neuroprotection in glaucoma. In addition, the trial leverages advanced biomarker imaging and functional testing to better measure patients’ glaucoma.
Foreseeable Benefits
This study will deliver key data on (1) CNTF-secreting implants as a new potential treatment for glaucoma; (2) the value of new ways of measuring glaucoma; and (3) how to properly power multicenter pivotal Phase 3 trials in neuroprotection, to follow.
Grants
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