IOP-Related Gene Responses in the Optic Nerve Head and Trabecular Meshwork

Project Goals

The goal of this project is to investigate how mild and repeat intraocular eye pressure elevations modify the molecular mechanisms in ocular tissues (trabecular meshwork and optic nerve head) implicated in glaucoma pathogenesis. 

Project Summary

Elevated intraocular pressure (IOP) is a leading risk factor for primary open-angle glaucoma. Yet, the cellular events that comprise protective homeostatic IOP responses, or deleterious events leading to tissue injury, are currently poorly understood. We will investigate how mild and repeat IOP elevations modify the molecular mechanisms in ocular tissues implicated in glaucoma pathogenesis.

Publications

First published on: August 05, 2024

Last modified on: December 22, 2024