Identifying and Studying the Molecules Sensing the Pressure in the Eye
Detailed Non-Technical Summary
Uniqueness: - Identification of the molecular sensors mediating the effect of eIOP on retinal cell death and loss of vision in laboratory models and human eyes Innovation: - The use existing pharmacological and genetic approaches to confirm the role of the molecular sensors in glaucoma will speed up the process of validation. - Pharmacological approaches may lead to rapid identification and use of existing drugs, specifically modulating the Piezo channels, to reduce eIOP and block retinal cell death.Biological: Our study may advance the general knowledge of the molecular mechanisms sensing IOP in the eye. Clinical: Clinical trials using existing modulators of Piezo channel activity can be performed. Assessing safety and efficacy of these Piezo channels modulators on retinal cell death and loss of vision in patients with glaucoma.