How the Microenvironment Affects Schlemm’s Canal Cell Behavior

Project Goals

The goal of this project is to investigate the role of glaucomatous cellular and biomechanical trabecular meshwork cues in driving abnormal Schlemm’s canal cell mechanotransduction processes.

Project Summary

High-pressure glaucoma is a leading cause of blindness worldwide, but the causal mechanisms are unclear. Using our unique 3D fluid drainage tissue model system, we seek to investigate the contributions of glaucomatous biomechanical cues in driving Schlemm’s canal cell mechano-dysfunction. This work will set the stage for identification of future glaucoma therapies targeting cellular biomechanics. 

Publications

First published on: August 05, 2024

Last modified on: November 27, 2024