Functional Roles of Optineurin in RGC-5 cells
Principal Investigator
Project Goals
This study examines how proteins are transported inside cells and how neurites grow. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.
Project Summary
The researchers will study the roles of optineurin, a glaucoma gene, in two cellular functions in neuronal cells. One functions relates to the transportation of proteins inside cells, and the other governs whether and how neurites extend or grow in the cells. This study will provide new information about the role of optineurin in these important functions. It should also help explain why and how abnormal levels or mutations of optineurin may lead to glaucoma. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.
Publications
Koga, T., Shen, X., Park, J., Qiu, Y., Park, B.C., Shyam, R. and Yue, B.Y.J.T. (2010) Differential Effects of Myocilin and Optineurin, Two Glaucoma Genes, on Neurite Outgrowth. Am. J. Pathol. 176, 343-352 
Ying, H., Shen, X., Park, B.C. and Yue, B.Y.J.T. (2010) Posttranslational modification, localization and protein protein interactions of optineurin. PLoS One 5:e9168.
First published on: June 11, 2008
Last modified on: November 22, 2024