Defining the Role of a New Protein Target in Fluid Buildup in Glaucoma

Principal Investigator

Co-Principal Investigator

  • Pratap  Challa, MD

    Pratap Challa, MD

    Duke University School of Medicine
    Durham, NC
  • Vasantha Rao, PhD

    Duke University School of Medicine
    Durham, NC

Project Goals

The goal of this project is to define the glaucoma-related role of an important protein in the eye's fluid drainage system.

Project Summary

The eye's drainage system for fluid is a spongy region called the trabecular meshwork. In glaucoma, dysfunction of this tiny drainage area can lead to fluid buildup, creating high pressure in the eye. Like other cells, trabecular network cells have an internal transportation system that must function properly for the tissue to do its job. Septins are proteins that contribute to the structure of this transportation system, and genetic studies have implicated septins in glaucoma.

To connect these dots and identify potential treatment targets in glaucoma, Rupalatha Maddala, PhD, and her team plan to take a deep dive into the role of septins in trabecular meshwork regulation of fluid outflow and its potential role in fluid buildup in glaucoma.

Their project represents the first exploration of the potential role of septins in glaucoma. The team expects the findings to highlight specific features of septins and their role in fluid pressure in the eye that could be targets in glaucoma treatment.

Publications

First published on: September 12, 2023

Last modified on: April 14, 2024