Can WashOut be induced in the human eye to reduce IOP?
Principal Investigator
Project Summary
In order to be transparent so that vision is possible, some of the tissues of the eye have no blood supply. These tissues depend upon a clear nutritive fluid called aqueous humor in order to survive. Used aqueous humor leaves the eye through a specially designed filtration tissue known as the trabecular meshwork. The finest mesh of this filer is called the juxtacanalicular region (JCT). After flowing through the JCT, used aqueous humor passes through the inner wall lining cells of Schlemm's canal and into the veins leaving the eye. Disruption of connectivity between the inner wall of Schlemm's canal and the JCT is predicted to increase aqueous humor outflow facility and may lead to the development of novel therapeutic agents for the treatment of the elevated pressure associated with glaucoma.
Publications
Scott PA, Overby DR, Freddo TF, Gong H: Comparative studies between species that do and do not exhibit the washout effect. Exp. Eye Res, 84:435-443,2007. 
Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 2008 Feb;86(2):271-81. Epub 2007 Nov 5.
Gong H and Freddo TF: The Washout Phenomenon in Aqueous Outflow - Why Does It Matter? Exp Eye Res, 88: 729-737, 2009.
Battista SA, Lu Z, Hofmann S, Freddo TF, Overby DR, Gong H: Acute IOP elevation reduces the available area for aqueous humor outflow and induces meshwork herniations into collector channels of bovine eyes. Invest. Ophthalmol. Vis. Sci., 49:5346-52, 2008.
Lu Z, T. Freddo, TF and Gong H: The Mechanism of Rho-Kinase Inhibitor, Y27632, on Outflow Facility in Monkey vs Human Eyes. Invest. Ophthalmol. Vis. Sci. 200748: E-Abstract 1146. [conference abstract] Lu Z, Scott PA, Hofmann S, Overby DR, Freddo TF, Gong H: The Mechanism of Increasing Outflow Facility by Rho-Kinase Inhibition with Y27632 in Bovine Eyes. Invest. Ophthalmol. Vis. Sci., 2006 47: Abstract 1856 [conference abstract]
First published on: June 11, 2008
Last modified on: November 26, 2023