Association Between Glaucoma and Sleep Disorders
Detailed Non-Technical Summary
Glaucoma patients have a high incidence of sleep disorders. While the ventrolateral preoptic nucleus, the main sleep-inducing hub, receives the input from intrinsically photosensitive retinal ganglion cells known to be impaired in glaucoma, no studies have yet examined how the sleep-regulating systems are affected by glaucoma. This proposal will provide a mechanistic account of glaucoma pathogenesis that underlies sleep disorders. Mainly, this study will reveal if alterations in the functional connectivity and neurochemical balance underlie sleep disorders in glaucoma. The outcomes of this project will provide a better understanding of glaucoma pathogenesis that underlies sleep disorders. Furthermore, the outcomes will advance clinical treatments for glaucoma patients who suffer from sleep disorders.