The Novel Role of an Intracellular Nuclear Receptor in AMD Pathogenesis
Principal Investigator
Mentors
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Jing Chen, PhD
Project Goals
This project aims to uncover the mechanisms by which a lipid-sensing nuclear receptor RORa links lipid dysregulation with abnormal macrophage recruitment and chronic inflammation in AMD pathogenesis.
Project Summary
Age-related macular degeneration (AMD) is a leading cause of blindness among people aged 60 and older. It is a multifactorial disease involving multiple cellular pathways, among which lipid dysregulation and inflammation are major pathogenic factors. Researchers will investigate the role of a lipid-sensing nuclear receptor retinoic acid-related orphan receptor alpha (RORa) in regulating chronic subretinal inflammation to elucidate AMD pathogenesis. They will assess if genetic deletion of RORa in a type of inflammatory cells may lead to lipid dysregulation and chronic inflammation.
Publications
First published on: August 02, 2024
Last modified on: September 11, 2024