Non-invasive Laser Photography of the Living Human Retina to Understand Cells
Detailed Non-Technical Summary
Two-photon functional imaging of the retina, while used extensively by our group in animals and in vitro, has never been achieved in human retinal imaging. We will produce a first-of-its-class research device to study human retinal disease. We contribute new safety data to make 2-photon imaging practical in human eyes. We will unearth, heretofore, unobtainable information about retinal tissue function in living humans with macular degeneration. We will create a new imaging device that will help us understand common and uncommon blinding diseases non-invasively, open avenues to treatments targeting the early stages of the disease, and ultimately prevent vision loss.