A murine model of AMD with CNV and sub-RPE deposits

Principal Investigator

Project Summary


A gene that has been implicated as a risk factor in age-related macular degeneration (AMD) is apolipoprotein E, or apoE. The human apoE gene exists in three variations or alleles, designated as apoE2, -E3 and -E4. Dr. Bowes-Rickman is studying the relative roles of each form of apoE, along with aging and diet, on the structural integrity of the retina and its adjacent blood supply in a potential mouse model of AMD. She has hypothesized that the combination of three major risk factors for AMD―apoE isoform expression, aging and diet―cause pathological changes in the retina, including the formation and accumulation of debris under the retinal pigmented epithelium (RPE) and new blood vessel growth. Her goal is to produce a mouse model that closely approximates these features of human AMD. This murine model can then be induced to express the defining events that lead to choroidal neovascularization in late AMD and provide a model for testing new therapies.

Publications

Malek, G., Mace, B., Saloupis, P., Schmechal, D., Rickman, D., Sullivan, P., and Rickman, C.B. (2006) Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice. Adv. Exp. Med. Biol. 572:109-117.  

Malek G, Johnson L, Mace BE, Saloupis, P, Schmechel DE, Rickman D, Toth CA, Sullivan PM, Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration. Proc, Natl. Acad. Sci. USA 2005;102 (33) 11900-11905  
 

First published on: June 11, 2008

Last modified on: February 25, 2024