Interplay Between Inflammation and Cell Metabolism in AMD
Little is known about the interplay between inflammatory and metabolic dysfunction in the retinal pigment epithelium. By unraveling the precise mechanisms governing this interplay, we can find novel metabolic targets and test their efficacy in dampening the inflammatory response, thereby opening innovative therapeutic approaches to treat age-related macular degeneration. Understanding the interplay of inflammation and metabolism in RPE will enhance our understanding of the pathogenesis of age-related macular degeneration (AMD) and enable the identification of novel drug targets for treating AMD and restoring vision. The findings from this study will also enhance our foundational biological understanding of inflammation and metabolism and serve to inspire more studies investigating this relationship in other diseases with an inflammatory component.