Centre for Eye Research Australia, The University of Melbourne
Melbourne, Australia
Genetic risks for AMD in Australians of Northern and Southern European origin
Principal Investigator
Project Goals
This study will investigate whether the risk of AMD, which is pre-determined by genes, can be modified by changes in diet. The study will genotype AMD cases and controls from a large Australian cohort of participants of Anglo-Celtic and Mediterranean origin to define genetic risk for AMD.
Project Summary
This study will investigate whether the risk of AMD, which is pre-determined by genes, can be modified by changes in diet. The study will genotype AMD cases and controls from a large Australian cohort of participants of Anglo-Celtic and Mediterranean origin to define genetic risk for AMD. They will identify the AMD genes in elderly from this cohort (about 8,000 people), and correlate genetic status of the participants with their dietary history and condition of the retina. This might be a first step towards personalized medical care, based upon knowledge of susceptibility to a disease using genetic and other risk factor information.
Publications
Adams MK, Simpson JA, Aung KZ, Makeyeva GA, Giles GG, English DR, Hopper J, Guymer RH, Baird PN, Robman LD. Am J Epidemiol. Abdominal Obesity and Age-related Macular Degeneration. 2011 Mar 21. 
Adams MK, Simpson JA, Richardson AJ, Guymer RH, Williamson E, Cantsilieris S, English DR, Aung KZ, Makeyeva GA, Giles GG, Hopper J, Robman LD, Baird PN. Hum Mol Genet. 2012 Sep 17.
First published on: June 11, 2008
Last modified on: November 19, 2024