The Generation of Cone Photoreceptor Outer Segments 

Project Summary

The loss of cone photoreceptor cells during age-related macular degeneration (AMD) can lead to irreversible vision loss. Repairing these specialized cells could change the overall approach of AMD therapies and complement current treatment options. This research investigates how cone photoreceptor outer segments are formed and regenerated using stem cell organoids and the brown anole lizard, a novel research model for cone photoreceptor diseases. Findings will identify a new strategy and potential new therapeutic targets to improve and prevent loss of cone photoreceptor cell function during AMD.