Functional Study of HTRA1 and Age-Related Macular Degeneration
About the Research Project
Program
Award Type
Standard
Award Amount
$100,000
Active Dates
April 01, 2008 - March 31, 2010
Grant ID
M2008092
Goals
Identification and functional studies of the HTRA1, a gene that has substantial impact on the risk of AMD, may define key molecular pathways involved in its pathogenesis. The experiments will yield novel mechanistic insights relevant to the pathogenesis of both early and late AMD. This may lead to therapies directed at the underlying cause and pre-symptomatic diagnosis leading to earlier intervention.
Summary
Identification and functional studies of the HTRA1, a gene that has substantial impact on the risk of AMD, may define key molecular pathways involved in its pathogenesis. The experiments will yield novel mechanistic insights relevant to the pathogenesis of both early and late AMD. This may lead to therapies directed at the underlying cause and pre-symptomatic diagnosis leading to earlier intervention.
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