Randall Bateman, MD

Washington University School of Medicine
St. Louis, MO

Dr. Bateman received B.S. degrees in electrical engineering and biology from Washington University and his medical degree from Case Western Reserve University School of Medicine. He completed a neurology residency at Barnes Jewish Hospital and did post-doctoral research at Washington University School of Medicine, where he is the Charles F. and Joanne Knight Distinguished Professor of Neurology, director of the Dominantly Inherited Alzheimer Network (DIAN), and director of the DIAN Trials Unit (DIAN-TU). Dr. Bateman’s research focuses on the pathophysiology and development of improved diagnostics and treatments of Alzheimer’s disease (AD). The accomplishments of his lab include pioneering the central nervous system Stable Isotope Labeling Kinetics (SILK) measurements in humans, furthering insights of human circadian patterns of amyloid-beta (Aβ) and soluble amyloid precursor protein (APP), and human in vivo control of the alpha-secretase, beta-secretase, and gamma-secretase processing of Aβ.  His lab has developed methods to quantify the pharmacodynamic action of drugs targeting Aβ, APP, and apolipoprotein E. Dr. Bateman’s research in DIAN has provided evidence for a cascade of events beginning decades before symptom onset that leads to AD dementia. He has received a number of awards including the Beeson Award for Aging Research, Alzheimer’s Association (Zenith Award), Scientific American, Chancellor’s Award for Innovation and Entrepreneurship (Washington University), the Glenn Award for Aging Research, and the MetLife Foundation Award for Medical Research. Dr. Bateman has been the primary mentor for junior faculty, clinical fellows, post-doctoral researchers, and graduate and medical students, who have been successful in their desired scientific careers.

Publications

Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ. SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases. Nat Rev Neurol. 2019 Jun 20. doi: 10.1038/s41582-019-0222-0. [Epub ahead of print] Review. PubMed PMID: 31222062. PubMed IconGoogle Scholar Icon

Bateman, R. J., Mawuenyega, K. G., & Wildburger, N. C. (2019). The structure of amyloid-β dimers in Alzheimer’s disease brain: a step forward for oligomers. Brain, 142(5), 1168-1169. PMID: 31032843 DOI: 10.1093/brain/awz082 PubMed IconGoogle Scholar Icon