Jaehong Suh, PhD

Dr. Jaehong Suh joined the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH) in 2006 as a postdoctoral research fellow. In the Suzanne Guenette lab, he studied the effects of FE65 and FE65L1 loss of functions on APP metabolism and lens integrity. In the Rudy Tanzi lab, he studied in vivo pathogenic mechanisms of ADAM10 mutations found in late-onset Alzheimer’s disease families. Dr. Suh was promoted to assistant professor of neurology in 2014, established his lab, and continued the research to elucidate the underlying mechanisms of Alzheimer’s and identify viable therapeutic targets. More recently, Dr. Suh has been studying the role of ataxin-1 in BACE1 expression and Alzheimer’s disease pathogenesis and exploring if down-regulation of BACE1 can be developed as a therapy for spinocerebellar ataxia, a neurodegenerative disease that impairs motor coordination and balance. Before joining MGH, he studied neuronal death mechanisms and tau splicing in ischemic brain at Ajou University School of Medicine in South Korea. Dr. Suh received both his BS and PhD degrees from Korea Advanced Institute of Science and Technology. For his PhD thesis, Dr. Suh studied the mechanisms of dioxin- and polychlorinated biphenyls-induced adverse effects on immune functions. Dr. Suh’s research at MGH has been supported through grants from NIH, Cure Alzheimer’s Fund, Massachusetts Center for Alzheimer Therapeutics Science, and BrightFocus Foundation.