Elizabeth Head, PhD, directs the University of Kentucky Aging Study in Down Syndrome, consisting of a cohort of more than 70 adults with DS, a cohort made up primarily of individuals without dementia, as well as a smaller group of individuals with dementia who have been followed for up to eight years. This study has been funded by the NIH/NICHD (R01HD064993). Dr. Head has published extensively in the DS, aging, and dementia field, with over 50 papers in this area. She has contributed to several books and special topics issues dedicated to describing research in aging adults with DS. She brings her expertise in lifespan changes in brain proteins that may contribute to AD (AD) in DS. Her current work is focused on cerebrovascular dysfunction and white matter integrity losses as underlying pathologies contributing to the development of dementia in DS. Dr. Head has a background of working on autopsy tissue from DS donors, having served as co-leader of the University of California-Irvine AD Research Center Neuropathology Core, and director of its brain Tissue Repository. She also has been involved with imaging studies in DS to detect structural, connectivity and cerebrovascular changes as a function of age and dementia.
University of California, Irvine