Twisting away toxic proteins in Alzheimer's Disease
Detailed Non-Technical Summary
This project seeks to reverse the pathological accumulation of toxic proteins in Alzheimer's Disease. There are three key portions: First, we will examine if certain proteins can work to accelerate, decelerate, or reverse how the tau protein accumulates in Alzheimer's disease. We will take measurements on how these proteins affect the physical state of tau that drives Alzheimer's disease progression. Second, we have data that at least one class of proteins we will examine can dramatically reverse the aggregation of tau commonly observed in Alzheimer's disease.