Targeting Brain Cell Miscommunication to Restore Memory in Alzheimer’s Disease
Principal Investigator
Project Goals
Identify and therapeutically target activity-dependent transcriptomic and molecular signatures underlying disrupted interneuron/astrocyte communication, which contributes to synaptic dysfunction.
Project Summary
The brain's ability to adapt and change, known as synaptic plasticity, requires the expression of specific genes and proteins in different brain cells, neurons and astrocytes, which is affected in brain disorders like Alzheimer's. In order to find potential therapeutic strategies to recover synaptic plasticity, cell communication, and to improve memory in Alzheimer’s, we will use advanced techniques in mouse models and lab-grown human cells with Alzheimer’s-like pathology. Our results will contribute to the development of improved treatments for patients with synaptic plasticity disorders.
Publications
First published on: October 10, 2024
Last modified on: October 15, 2024