The Role of Small RNAs in Alzheimer's Disease
Detailed Non-Technical Summary
Small RNAs (sRNAs) are short (12-200nt) non-coding regulatory RNAs that balance gene expression. In Alzheimer disease (AD), most of the studies have focused on micro RNAs (miRNAs), but miRNAs are not the most abundant sRNA species in tissues and biofluids. Thus, the relationship between AD pathophysiology and sRNAs beyond miRNAs is mostly unknown and the aim of the present proposal. In this study, one of the aims is to find a set of small RNAs that is specific enough to help in the detection and diagnosis of Alzheimer's Disease (AD). The delivery of a specific and cost-effective diagnostic tool will require further research, but at the completion of this study, we aim to propose a set of small RNAs useful to diagnose Alzheimer's Disease.
Ibanez L, Miller JB. Editorial for the Genetics of Alzheimer's Disease Special Issue: October 2021. Genes (Basel). 2021 Nov 14;12(11):1794. doi: 10.3390/genes12111794. PMID: 34828400; PMCID: PMC8619725.