The Role of the Immune System in Driving Cognitive Decline

Project Summary

During aging and Alzheimer's disease, certain inflammatory responses regulated by the immune system further exacerbate the disease and contribute to impaired cognition and memory. This study focuses on delineating the machinery necessary for immune cells to amplify damaging inflammation in the body and, ultimately, the brain. Using a novel method to target a specific immune cell mechanism, Dr. Ennerfelt and colleagues will assess how impeding its associated inflammatory pathways can curb cognitive decline and Alzheimer’s progression.