The Role of the Brain Vascular-Immune Processes in Alzheimer’s

Principal Investigator

Mentors

  • Sandra  Black, MD

    Sandra Black, MD

  • Maged  Goubran, PhD

    Maged Goubran, PhD

Project Goals

To investigate how vascular injury and inflammation in the brain contributes to Alzheimer's disease progression by utilizing multimodal and longitudinal in-vivo biomarker studies.

Project Summary

Damage to the brain's blood vessels can triple the risk of developing Alzheimer's disease, and overactive immune cells may further exacerbate this damage. Here, researchers will study how these vascular-immune responses affect Alzheimer’s progression by analyzing brain scans and blood samples from 500+ individuals over time. Study outcomes will present a unique and more detailed picture of key and understudied mechanisms driving Alzheimer’s, thereby opening new perspectives on the development of personalized biomarkers and treatment strategies that target the interface between the vascular system, brain immune cells, and Alzheimer’s.

Publications

First published on: July 30, 2024

Last modified on: October 10, 2024