Regulation of Microglia Phenotypes in Alzheimer’s Disease

Project Summary

Alzheimer's disease is defined by the accumulation of harmful proteins in the brain. Microglia, the immune cells of the brain, play a key role in this process, but the molecular mechanisms that lead to distinct phenotypes are unclear. This study will use advanced techniques to isolate and analyze microglia, revealing how they contribute to disease and identifying new targets for developing effective treatments. We will test the hypothesis that specific groups of protein families (MiT/TFE and AP-1), are responsible for controlling the genes that microglia turn on or off in Alzheimer's disease.