Proteomics of the Oxidative Phosphorylation System in AD

Project Summary

A reduced rate of brain metabolism is one of the best documented abnormalities in Alzheimer's disease (AD). Since abnormalities in mitochondrial energy production appear to play a major role in pathophysiology of AD, Dr. Breen plans to test the hypothesis that the proteins of the mitochondrial oxidative phosphorylation system are decreased or modified in the brains of AD patients. If data using a mouse model of AD demonstrate differences in the levels of the proteins of the oxidative phosphorylation system in AD versus control brains, then future studies will be directed towards examining these proteins in human AD brains. Identification of the factors involved in the etiology and/or progression of AD may lead to the development of treatments to improve neuropsychological function in AD patients or delay the onset of the disease.