Progranulin as a Potential Therapeutic Target for Alzheimer's Disease

Project Goals

This project aims to determine how progranulin enhances memory and to test if pharmacologically increasing progranulin levels can protect against Alzheimer’s disease.

Project Summary

Previous studies suggest that progranulin confers a protective effect on Alzheimer’s disease in mouse models and in humans, but several important gaps in knowledge exist. This project aims to determine how progranulin exerts its effects in the central nervous system to enhance memory and to test if pharmacologically increasing progranulin levels can protect against Alzheimer’s disease. 

Publications

First published on: August 01, 2024

Last modified on: December 22, 2024