Oxysterols in Innate and Adaptive Immunity in a Tauopathy Mouse Model

Project Summary

Neuronal loss in Alzheimer's disease is linked to brain infiltration of blood-derived immune cells in a neurotoxic cascade of tau protein accumulation and inflammation in the brain. Preliminary studies show evidence for altered brain cholesterol metabolism in mediating tau pathology and infiltration of blood immune cells into the brain. This project aims to investigate this pathway with the long-term goal of pharmacological intervention to block neuronal loss in Alzheimer’s.