Oxidative stress and amyloidogenesis
Principal Investigator
Summary
Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.
Detailed Non-Technical Summary
Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.
First published on: June 11, 2008
Last modified on: July 04, 2022