BrightFocus Foundation
BrightFocus Foundation

Novel Cerebrovascular Regulation in Alzheimer’s Disease

Principal Investigator

Laurie Erb, PhD

Laurie Erb, PhD

The Curators of the University of Missouri
Columbia, MO
Acknowledgement
This grant is made possible in part by a bequest from the Patsie Lee Clark Trust in memory of James Sterling Clark and Patsie Lee Clark.

Co-Principal Investigator

Project Goals

Alzheimer’s disease (AD) and other neurodegenerative diseases are often preceded by malfunctions in the cerebrovascular system (the brain’s blood vessels), including decreased blood flow in the brain, which leads to hypoxia (low oxygen levels), breakdown of the blood-brain barrier, and, ultimately, to brain atrophy and death. It is known that the endothelial cells that line blood vessels are important regulators of blood flow, and recent work indicates that a protein in endothelial cells (called P2Y2R) is activated under hypoxic conditions, causing relaxation of blood vessels and increases in blood flow. The recent work of Drs. Erb and Weisman with a mouse model of AD shows that global deletion of the P2Y2R (i.e., removal from all cell types) greatly accelerates nerve cell death and the appearance of other classic AD symptoms. Studies in this proposal will investigate whether cerebrovascular changes precede the development of AD symptoms in our AD mouse model, and whether the P2Y2R in endothelial cells, in particular, is important for mediating these events.

Project Summary

The studies of Drs. Erb and Weisman in this proposal will investigate whether cerebrovascular malfunctions, such as increased levels of hypoxia markers and vascular leakage, precede the development of AD symptoms in their AD mouse model. In particular, they will determine whether the P2Y2R in endothelial cells is important for mediating these events.

If endothelial P2Y2R regulation is substantiated in cerebrovascular function and the progression of AD in the mouse model used by Drs. Erb and Weisman, then this basic research study should provide the basis for specific therapeutic interventions to enhance vascular P2Y2R activity in AD patients, and, ultimately, improve cerebrovascular function and nerve cell survival.

First published on: July 01, 2013

Last modified on: May 02, 2024