Mechanisms of Inhibitory Neuron Vulnerability to Alzheimer’s Disease

Project Summary

Inhibitory interneurons, one of the key players in human cognitive processes, are among the first neuronal populations affected by AD onset. I propose their elevated energy consumption rates make these interneurons more vulnerable to AD. Using multiple innovative approaches, I will investigate three fundamental aspects underlying inhibitory interneuron vulnerability to AD. By completing the aims of my proposal, I expect to gain new insights into the pathological basis of this socially devastating neurological condition and contribute to develop novel therapeutic approaches.