Genetic Analysis of Presenilin Genes in Early Onset Alzheimer's Disease

Publications

van Duijn CM, Cruts M, Theuns J, Van Gassen G, Backhovens H, van den Broeck M, Wehnert A, Serneels S, Hofman A, Van Broeckhoven C. Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample. Eur J Hum Genet. 1999 Oct-Nov;7(7):801-6.

Besancon R, Lorenzi A, Cruts M, Radawiec S, Sturtz F, Broussolle E, Chazot G, van Broeckhoven C, Chamba G, Vandenberghe A. Missense mutation in exon 11 (Codon 378) of the presenilin-1 gene in a French family with early-onset Alzheimer's disease and transmission study by mismatch enhanced allele specific amplification. Mutations in brief no. 141. Hum Mutat. 1998;11(6):481.  

Cruts M, Van Broeckhoven C. Presenilin mutations in Alzheimer's disease. Hum Mutat. 1998;11(3):183-90. Review.  

Houlden H, Crook R, Backhovens H, Prihar G, Baker M, Hutton M, Rossor M, Martin JJ, Van Broeckhoven C, Hardy J. ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families. Am J Med Genet. 1998 Feb 7;81(1):117-21.  

[Book chapter] Cruts, M. and Van Broeckhoven, C. In: Blue Books of Practical Neurology: The Dementias, J.H. Growdon, M.N. Rossor, eds, Butterworrh-Heinemann (1998), 'Molecular genetics of Alzheimer's disease' pp. 155-170.

Cruts M, van Duijn CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofman A, Van Broeckhoven C. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet. (1998) Jan;7(1):43-51.