ER-Mitochondrial interactions in familial Alzheimer's disease
Principal Investigator
Project Goals
ER-Mitochondrial interactions in familial Alzheimer's disease
Project Summary
We have discovered that presenilin-1, a protein that, when mutated, causes familial (i.e. inherited) Alzheimer disease, is located in a specialized compartment of the cell, called endoplasmic reticulum-mitochondria-associated membranes (ER-MAM). This novel finding suggests a new mechanism by which the disease arises. We propose a number of experiments aimed at understanding the role of ER-MAM in the pathogenesis of Alzheimer disease.
Publications
Area-Gomez E, de Groof AJC, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA (2009). Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am. J. Pathol. 175, 1810-1816. 
Schon EA, Area-Gomez, E (2010). Is Alzheimer's disease a disorder of mitochondria-associated membranes? J. Alz. Dis. , accepted for publication, pending minor revisions.
First published on: June 11, 2008
Last modified on: November 21, 2024