The Effect of Alzheimer's Disease on Neurons Across the Sleep/Wake Cycle
Principal Investigator
Mentors
Project Goals
To determine the activity disruptions in different neuronal subtypes across the sleep/wake cycle in freely behaving APP/PS1 mice, an Alzheimer’s disease mouse model.
Project Summary
In Alzheimer's disease, buildup of amyloid beta (Aβ) protein can result in sleep disturbances. Dr. Abedin and his team will investigate the activity of specific neuronal types in a genetically engineered mouse model of Alzheimer's disease to understand how Aβ affects neuronal activity during the sleep/wake cycle. This research could pave the way for therapeutic development aimed at restoring abnormal neuronal activity and potentially leading to a cure for Alzheimer's disease.
Publications
First published on: July 30, 2024
Last modified on: December 16, 2024