Does Alzheimer’s Disease Accelerate Brain Aging?

Project Summary

The hippocampus, a brain region crucial for learning and memory, generates new neurons throughout life. This process is damaged in people with Alzheimer’s disease, but the cause of these alterations is unknown. Dr. Llorens-Martín and her team will use high-quality human brain samples and cutting-edge genomic and microscopy methodologies to assess the toxicity of the environment that surrounds new neurons. Study findings will identify novel mechanisms responsible for hippocampal perturbation in Alzheimer’s and generate novel resources that allow faster and more accurate diagnosis of this condition.