Defining the Impact of Cytokine Signaling in Alzheimer’s Disease

Project Goals

This project aims to determine the mechanistic impact of a key immune pathway in AD pathology, potentially leading to novel approaches for AD immunotherapies.

Project Summary

Immune signals regulate brain homeostasis and are also a major driver of Alzheimer’s disease pathology. This study will investigate how astrocyte-microglia crosstalk via IL-33 cytokine impacts Alzheimer’s disease pathology and behavior. This work will determine the mechanistic impact of a key immune pathway in AD pathology and suggest the novel hypothesis that ECM disruption is linked to AD pathology.

Publications

First published on: October 09, 2024

Last modified on: December 25, 2024