Cognitive Performance in Adolescence, APOE and AD

About the Research Project
Program
Award Type
Standard
Award Amount
$50,000
Active Dates
April 01, 2002 - March 31, 2003
Grant ID
A2002229
Summary
Researchers have suggested that there is a relationship between cognitive performance early in life and the development of Alzheimer’s disease (AD) later in life, but few studies have directly tested this relationship. Also, there have been no investigations to examine whether the genetic factor, apolipoprotein E4 (ApoE4), modifies the possible relationship. There are two main goals of this investigation by Dr. Fritsch. First, he will use information from archived school records and yearbooks to study relationships between cognitive performance, grades and participation in school activities in adolescence and the development of AD in adulthood. Second, he will collect genetic material in order to study the possible modifying role of ApoE. These studies should lead to understanding the early roots of AD and help evaluate whether AD is a developmental process or a long-term chronic disorder.
Related Grants
Alzheimer's Disease Research
The Astrocyte Cell Surface Proteome in Alzheimer’s Disease
Active Dates
July 01, 2025 - June 30, 2027

Principal Investigator
Omar Peña-Ramos, PhD
Current Organization
Baylor College of Medicine
Alzheimer's Disease Research
Unraveling the Triggers to Myelin Damage in Alzheimer’s Disease
Active Dates
July 01, 2025 - June 30, 2028

Principal Investigator
Katerina Akassoglou, PhD
Current Organization
Gladstone Institutes
Alzheimer's Disease Research
The Role of DYRK1A in Altered Microglia Biology in a Cellular Model of Alzheimer’s Disease in Down Syndrome
Active Dates
January 01, 2025 - December 31, 2027

Principal Investigator
Frances Wiseman, PhD
Current Organization
University College London (UK)