Cancer-Like Metabolic Changes in Alzheimer's Disease Neurons

Project Summary

This research focuses on how metabolic changes impact gene expression and protein modifications in Alzheimer's Disease (AD). Using neurons from AD patients, we've identified disruptions in metabolic pathways leading to abnormal gene processing. Our study aims to understand how these changes contribute to key AD features, such as tau tangle formation. By understanding upstream metabolic pathways of AD pathology, we aim to identify potential intervention targets to rescue the loss of synaptic function and prevent neuronal cell death.