Assessing the Impact of Blood-Brain Barrier Dysfunction in Alzheimer’s Disease
Principal Investigator
Mentors
Project Goals
The goal of the project is to identify novel biomarkers and key targets for blood-brain barrier breakdown and explore how it may contribute to Alzheimer’s disease diagnosis and progression.
Project Summary
Blood-brain barrier (BBB) breakdown has been observed in various neurodegenerative diseases including Alzheimer’s disease. In a healthy brain, the BBB does not allow transportation of proteins or large molecules into the brain. However, due to BBB dysfunction, enhanced permeability of plasma-derived proteins can be observed in different parts of brain regions, and may lead to neurotoxicity, neuroinflammation, and oxidative stress. This project will identify novel biomarkers and key targets for BBB breakdown and explore how it may contribute to Alzheimer’s diagnosis and progression.
Publications
First published on: October 09, 2024
Last modified on: October 16, 2024